Naja naja atra

001 Venom nerve growth factor (v-NGF)

No.001
LOCUS    P61898( A58566)
DEFINITION Venom nerve growth factor (v-NGF)
SOURCE Naja atra (Chinese cobra)
COMMENT
[FUNCTION] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. It probably participates direcetly or indirectly in the toxic activity.
[SUBUNIT] Homodimer.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[SIMILARITY] Belongs to the NGF-beta family.
ORIGIN
001 edhpvhnlge hsvcdsvsaw vtkttatdik gntvtvmenv nldnkvykey ffetkcknpn
061 pepsgcrgid sshwnsycte tdtfikaltm egnqaswrfi rietacvcvi tkkkgn
LENGTH 116 aa
MOLECULAR WEIGHT 13064 Da

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002 Cobrotoxin precursor (CBT) (Short neurotoxin 1) (Atratoxin)

No.002
LOCUS    P60770 (AAR33035)( CAA73097)
DEFINITION Cobrotoxin precursor (CBT) (Short neurotoxin 1) (Atratoxin).
SOURCE Naja atra (Chinese cobra)
COMMENT
[FUNCTION] This three-finger toxin binds and inhibits the muscular nicotinic acetylcholine receptor (nAChR). Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Has a higher toxicity than cobrotoxin-b.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[MASS SPECTROMETRY] MW=6952; METHOD=MALDI; RANGE=22-83; NOTE=Ref.8.
[TOXIC DOSE] LD(50) is 0.09 mg/kg by subcutaneous injection.
[SIMILARITY] Belongs to the snake toxin family. Type I alpha-neurotoxin subfamily.
ORIGIN
001 mktllltllv vtivcldlgy tlechnqqss qtptttgcsg getncykkrw rdhrgyrter
061 gcgcpsvkng ieinccttdr cnn

LENGTH 83 aa
MOLECULAR WEIGHT 9262 Da

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003 kappa-cobrotoxin (Long neurotoxin homolog precursor)

No.003
LOCUS    CAA76846(O93422)
DEFINITION kappa-cobrotoxin(Long neurotoxin homolog precursor).
SOURCE Naja atra (Chinese cobra)
COMMENT
[FUNCTION] Binds with low affinity and weakly inhibits nicotinic acetylcholine receptor (nAChR).
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[SIMILARITY] Belongs to the snake toxin family.
ORIGIN
001 mktllltlvv vtivclalgy tltclicpek ycnkvhtcln gekicfkkyd qrkllgkryi
061 rgcadtcpvr kpreiveccs tdkcnh

LENGTH 86 aa
MOLECULAR WEIGHT 9815 Da

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004 cardiotoxin 1

No.004
LOCUS    AAB01539
DEFINITION cardiotoxin 1.
SOURCE Naja atra (Chinese cobra)
COMMENT
[FUNCTION] Cardiotoxin I is the component of the snake venom that is responsible for skeletal muscle necrosis. It also induces increases in capillary permeability that can be prevented by H1 histamine receptor antagonists, such as dephenhydramine, promethazine and cyproheptadine. This indicates that cardiotoxin may induce histamine release.
ORIGIN
001 mktllltlvv vtivcldlgy tlkcnklipi asktcpagkn lcykmfmmsd ltipvkrgci
061 dvcpknsllv kyvccntdrc n

LENGTH 81 AA
MOLECULAR WEIGHT 8992 Da

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005 phospholipase A2 [Naja naja]

No.005
LOCUS    CAA54802(P00598)(Q91133)
DEFINITION phospholipase A2 [Naja naja].
SOURCE Naja naja
COMMENT
[FUNCTION] PL2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (By similarity).
[CATALYTIC ACTIVITY] Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
[COFACTOR] Binds 1 calcium ion per subunit (By similarity).
[SUBUNIT] In contrast to the pancreatic enzymes, the molecules of venom phospholipases A2 are dimers of identical chains; the monomers appear to be inactive (By similarity).
[SIMILARITY] Belongs to the phospholipase A2 family. Group I subfamily.
FEATURES EC_number="3.1.1.4"
ORIGIN
001 mtpahllila avcvsplgas ssrpmplnly qfknmiqctv psrswwdfad ygcycgrggs
061 gtpvddldrc cqvhdhcyne aekisgcwpy sktysyecsq gtltckggnn acaaavcdcd
121 rlaaicfaga pynnnnynid lkarcq

LENGTH 146 AA
MOLECULAR WEIGHT 15949 Da

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