Naja naja kaouthia

006 Venom nerve growth factor (v-NGF)

No.006
LOCUS    P61899
DEFINITION Venom nerve growth factor (v-NGF)
SOURCE Naja kaouthia (monocled cobra)
COMMENT
[FUNCTION] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons as well as basal forebrain cholinergic neurons in the brain. Its relevance in the snake venom is not clear. It probably participates direcetly or indirectly in the toxic activity.
[SUBUNIT] Homodimer
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[SIMILARITY] Belongs to the NGF-beta family.
ORIGIN
001 edhpvhnlge hsvcdsvsaw vtkttatdik gntvtvmenv nldnkvykey ffetkcknpn
061 pepsgcrgid sshwnsycte tdtfikaltm egnqaswrfi rietacvcvi tkkkgn
LENGTH 116 aa
MOLECULAR WEIGHT 13064 Da

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007 Cobra venom factor precursor (CVF) (Complement C3 homolog) [Contains: Cobra venom factor alpha chain; Cobra venom factor gamma chain; Cobra venom factor beta chain]

No.007
LOCUS    Q91132(I51018)(AAA68989)
DEFINITION Cobra venom factor precursor (CVF) (Complement C3 homolog) [Contains: Cobra venom factor alpha chain; Cobra venom factor gamma chain; Cobra venom factor beta chain].
SOURCE Naja kaouthia (monocled cobra)
COMMENT
[FUNCTION] Complement-activating protein in cobra venom.
[SUBUNIT] Heterotrimer of alpha, beta and gamma chains;
disulfide-linked.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[PTM] First processed by the removal of 4 Arg residues by furin-type protease, forming two chains, alpha and gamma/beta precursor, linked by a disulfide bond. Probably, the cobrin cleaves the C3a-like domain and then the C3d-like domain, generating the mature cobra venom factor (CVF). This mature CVF is composed of three chains: alpha, gamma and beta. These chains are linked by a disulfide bond between the alpha and gamma chains and another one between the gamma and beta chains.
[SIMILARITY] Contains 1 anaphylatoxin-like domain.
[SIMILARITY] Contains 1 NTR domain.
ORIGIN
0001 mermalylva alligfpgss hgalytlitp avlrtdteeq ilveahgdst pkqldifvhd
0061 fprkqktlfq trvdmnpagg mlvtptieip akevstdsrq nqyvvvqvtg pqvrlekvvl
0121 lsyqssflfi qtdkgiytpg spvlyrvfsm dhntskmnkt vivefqtpeg ilvssnsvdl
0181 nffwpynlpd lvslgtwriv akyehspeny tayfdvrkyv lpsfevrlqp sekffyidgn
0241 enfhvsitar ylygeevegv afvlfgvkid dakksipdsl tripiidgdg katlkrdtfr
0301 srfpnlnelv ghtlyasvtv mtesgsdmvv teqsgihiva spyqihftkt pkyfkpgmpy
0361 eltvyvtnpd gspaahvpvv seafhsmgtt lsdgtaklil niplnaqslp itvrtnhgdl
0421 prerqatksm taiayqtqgg sgnylhvait steikpgdnl pvnfnvkgna nslkqikyft
0481 ylilnkgkif kvgrqprrdg qnlvtmnlhi tpdlipsfrf vayyqvgnne ivadsvwvdv
0541 kdtcmgtlvv kgdnliqmpg aamkiklegd pgarvglvav dkavyvlndk ykisqakiwd
0601 tieksdfgct agsgqnnlgv fedaglaltt stnlntkqrs aakcpqpanr rrrssvllld
0661 snaskaaefq dqdlrkcced vmhenpmgyt cekrakyiqe gdackaafle ccryikgvrd
0721 enqreselfl arddnedgfi adsdiisrsd fpkswlwltk dlteepnsqg issktmsfyl
0781 rdsittwvvl avsftptkgi cvaepyeirv mkvffidlqm pysvvkneqv eirailhnyv
0841 nediyvrvel lynpafcsas tkgqryrqqf pikalssrav pfvivpleqg lhdveikasv
0901 qealwsdgvr kklkvvpegv qksivtivkl dprakgvggt qlevikarkl ddrvpdteie
0961 tkiiiqgdpv aqiiensidg sklnhliitp sgcgeqnmir maapviatyy ldtteqwetl
1021 ginrrteavn qivtgyaqqm vykkadhsya aftnrasssw ltayvvkvfa maakmvagis
1081 heiicggvrw lilnrqqpdg afkenapvls gtmqggiqga eeevyltafi lvalleskti
1141 cndyvnslds sikkatnyll kkyeklqrpy ttaltayala aadqlnddrv lmaastgrdh
1201 weeynahthn iegtsyalla llkmkkfdqt gpivrwltdq nfygetygqt qatvmafqal
1261 aeyeiqmpth kdlnlditie lpdrevpiry rinyenalla rtvetklnqd itvtasgdgk
1321 atmtiltfyn aqlqekanvc nkfhlnvsve nihlnamgak galmlkictr ylgevdstmt
1381 iidismltgf lpdaedltrl skgvdryisr yevdnnmaqk vaviiylnkv shsedeclhf
1441 kilkhfevgf iqpgsvkvys yynldekctk fyhpdkgtgl lnkicignvc rcagetcssl
1501 nhqeridvpl qiekacetnv dyvyktkllr ieeqdgndiy vmdvlevikq gtdenprakt
1561 hqyisqrkcq ealnlkvndd yliwgsrsdl lptkdkisyi itkntwierw phedecqeee
1621 fqklcddfaq fsytltefgc pt
LENGTH 1642 aa
MOLECULAR WEIGHT 184518 Da

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008 Cobrotoxin precursor (CBT) (Short neurotoxin 1) (NT1)

No.008
LOCUS    P60771(AAY63884)
DEFINITION Cobrotoxin precursor (CBT) (Short neurotoxin 1) (NT1).
SOURCE Naja kaouthia (monocled cobra)
ORIGIN
001 mktllltllv vtivcldlgy tlechnqqss qtptttgcsg getncykkrw rdhrgyrter
061 gcgcpsvkng ieinccttdr cnn
LENGTH 83 aa
MOLECULAR WEIGHT 9262 Da

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009 phospholipase A2 [Naja kaouthia]

No.009
LOCUS    BAA36404(BAA36403)(P00596)(P00597)
DEFINITION phospholipase A2 [Naja kaouthia].
SOURCE Naja kaouthia (monocled cobra)
COMMENT
[FUNCTION] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
[CATALYTIC ACTIVITY] Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
[COFACTOR] Binds 1 calcium ion per subunit (By similarity).
[SUBCELLULAR LOCATION] Secreted protein.
[TOXIC DOSE] LD(50) is 10 mg/kg by intravenous injection.
[SIMILARITY] Belongs to the phospholipase A2 family. Group I subfamily.
FEATURES EC_number="3.1.1.4"
ORIGIN
001 mnpahllila avcvsslgas snrpmplnly qfknmiqctv psrswwdfad ygcycgrggs
061 gtpvddldrc cqvhdncyne aekisgcwpy fktysyecsq gtltckggnn acaaavcdcd
121 rlaaicfaga pynnnnynid lkarcq
LENGTH 146 aa
MOLECULAR WEIGHT 16271 Da

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