Ophiophagus Hannah

010 Phospholipase A2, acidic 1 precursor (Phosphatidylcholine 2-acylhydrolase) (APLA2-1) (OHV A-PLA2) (OHV-APLA2)

No.010
LOCUS    P80966
DEFINITION Phospholipase A2, acidic 1 precursor (Phosphatidylcholine 2-acylhydrolase) (APLA2-1) (OHV A-PLA2) (OHV-APLA2).
SOURCE Ophiophagus hannah (king cobra)
COMMENT
[FUNCTION] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Exhibits cardiotoxicity, myotoxicity, antiplatelet activity, and edema-inducing activity.
[CATALYTIC ACTIVITY] Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
[COFACTOR] Binds 1 calcium ion per subunit (By similarity).
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[SIMILARITY] Belongs to the phospholipase A2 family. Group I subfamily.
FEATURES EC_number="3.1.1.4"
ORIGIN
001 mnpahllvls avcvsllgas sippqplhli qfgnmiqctv pgflswikya dygcycgagg
061 sgtpvdkldr ccqvhdncyt qaqklpacss imdspyvkiy sydcsertvt ckadndecaa
121 ficncdrvaa hcfaaspynn nnynidtttr c
LENGTH 151 AA
MOLECULAR WEIGHT 16444 Da

^TOP^

011 Long neurotoxin 1 (Neurotoxin A).

No.011
LOCUS    P01387
DEFINITION Long neurotoxin 1 (Neurotoxin A).
SOURCE Ophiophagus hannah (king cobra)
COMMENT
[FUNCTION] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[TOXIC DOSE] LD(50) is 0.3 mg/kg by subcutaneous injection.
[SIMILARITY] Belongs to the snake toxin family. Type II alpha-neurotoxin subfamily.
ORIGIN
001 tkcyvtpdvk setcpagqdi cytetwcdaw ctsrgkrvdl gcaatcpivk pgveikccst
061 dncnpfptwr krp
LENGTH 73 aa
MOLECULAR WEIGHT 8106 Da

^TOP^

012 Long neurotoxin 2 (Neurotoxin B)

No.012
LOCUS    P01386
DEFINITION Long neurotoxin 2 (Neurotoxin B).
SOURCE Ophiophagus hannah (king cobra)
COMMENT
[FUNCTION] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (only alpha-7 alpha-8 alpha-9) nicotinic acetylcholine receptors (By similarity).
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[TOXIC DOSE] LD(50) is 0.35 mg/kg by subcutaneous injection.
[SIMILARITY] Belongs to the snake toxin family. Type II alpha-neurotoxin subfamily.
ORIGIN
001 tkcyvtpdat sqtcpdgqdi cytktwcdgf cssrgkridl gcaatcpkvk pgvdikccst
061 dncnpfptwk rkh
LENGTH 73 aa
MOLECULAR WEIGHT 8053 Da

^TOP^

ap.html" />