Bungarus fasciatus

013 Short neurotoxin 1 (Toxin V-II-1)

No.013
LOCUS    P10808
DEFINITION Short neurotoxin 1 (Toxin V-II-1).
SOURCE Bungarus fasciatus (banded krait)
COMMENT
[FUNCTION] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[SIMILARITY] Belongs to the snake toxin family. Type I alpha-neurotoxin subfamily.
ORIGIN
001 riclnqqqst pedqptngqc yiktdcqnkt wnthrgsrtd rgcgcpkvkp ginlrccktd
061 kcne
LENGTH 64 aa
MOLECULAR WEIGHT 272 Da

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014 Short neurotoxin 2 (Toxin V-II-2) (Fasciatoxin)

No.014
LOCUS    P14534
DEFINITION Short neurotoxin 2 (Toxin V-II-2) (Fasciatoxin).
SOURCE Bungarus fasciatus (banded krait)
COMMENT
[FUNCTION] Blocks both the muscle-twitch response to nerve stimulation and the response to exogenous acetylcholine.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[MISCELLANEOUS] In contrast to other snake toxins the action of this toxin is reversible.
[MISCELLANEOUS] Unusual amino acid sequence distinctly different from other short-chain type toxins.
[SIMILARITY] Belongs to the snake toxin family. Orphan group XVIII subfamily.
ORIGIN
001 lkchkaqfpn ietqckwqtl cfqrdvkphp ssmivlrgct sscgkgamcc atdlcngpst
061 pst
LENGTH 63 aa
MOLECULAR WEIGHT 6847 Da

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015 Acetylcholinesterase precursor (AChE)

No.015
LOCUS    Q92035
DEFINITION Acetylcholinesterase precursor (AChE).
SOURCE Bungarus fasciatus (banded krait)
COMMENT
[FUNCTION] Rapidly hydrolyzes choline released into the synapse.
[CATALYTIC ACTIVITY] Acetylcholine + H(2)O = choline + acetate.
[SUBUNIT] Isoform S is monomeric. Isoform T can form oligomers, including collagen-tailed forms.
[SUBCELLULAR LOCATION] Secreted protein.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=T; IsoId=Q92035-2; Sequence=Displayed; Name=S; IsoId=Q92035-1; Sequence=VSP_008215.
[TISSUE SPECIFICITY] Liver and muscle contain both isoform T and isoform S. Venom gland predominantly contains isoform S.
[PTM] The N-terminus is blocked.
[SIMILARITY] Belongs to the type-B carboxylesterase/lipase family.
[CAUTION] It is uncertain whether Met-1 or Met-9 is the initiator.
FEATURES EC_number="3.1.1.7"
ORIGIN
001 mpscqpgkmp apwpwwlqll lcipscvavl pgragelkvs tqtgsvrgls lpvldghvsa
061 flgipfaepp lgrmrflrpe pvkpwqhvld atsykpacyq mvdtsypgfq gtemwnpnrg
121 msedclylni wvpsprpkda pvlvwiyggg fysgaasldv ydgrfltytq nvilvslsyr
181 vgafgflglp gspeapgnmg lldqrlalqw iqnnihpfgg npravtvfge sagaasvgmh
241 llstqsrtlf qrailqsggp napwatvtpa esrgraallg kqlgchfnnd selvsclrsk
301 npqelideew svlpyksifr fpfvpvidgd ffpdtpeaml ssgnfketqv llgvvkdegs
361 yfliyglpgf skdneslisr adflegvrms vphandiatd avvlqytdwq dqdnreknre
421 alddivgdhn vicpvvqfan dyakrnskvy aylfdhrasn llwppwmgvp hgyeiefvfg
481 lplndslnyt pqekelsrrm mrywanfart gnptdpadks gawptytasq pqyvqlntqp
541 latqpslraq icafwnhflp kllnatdnie eaerqwklef hlwsaymmhw ksqfdhynkq
601 drcsel

LENGTH 606 aa
MOLECULAR WEIGHT 68074 Da

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