Deinagkistrodon acutus

020 Acutobin precursor (Acuthrombin) (Acutase). thrombin-like protein precursor thrombin-like protein acutobin precursor

No.020
LOCUS    Q9I8X2(AAF76377)(AAF76380)
DEFINITION Acutobin precursor (Acuthrombin) (Acutase). thrombin-like protein precursor. thrombin-like protein acutobin precursor
SOURCE Deinagkistrodon acutus
COMMENT
[FUNCTION] Thrombin-like snake venom serine protease. Has a blood clotting activity.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Expressed by the venom gland.
[PTM] N-glycosylated.
[SIMILARITY] Belongs to the peptidase S1 family. Snake venom subfamily.
[SIMILARITY] Contains 1 peptidase S1 domain.
FEATURES EC_number="3.4.21.-"
ORIGIN
001 mvlirvlanl lilqlsyaqk sselviggve cdinehrflv alyeltsmtf lcggtlinqe
061 wvvtaahcdr lqlylyigmh dkyvkfddeq grepiekyfy ncsnnlttrd kdimlirldr
121 pvdnsthiap lslpsrppsv gsvcrvmgwg aispsrdvlp dvphcvninl vnnaecrray
181 prlpatsrtl cagvmqggid scnrdsggpl icdgqfqgvv nwggnpcaqp nmpalytkvy
241 dyndwirsit agnttaacpp
LENGTH 260 aa
MOLECULAR WEIGHT 28815 Da

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021 Phospholipase A2, basic isoform precursor (Phosphatidylcholine)

No.021
LOCUS    Q1ZY03(CAA11159)(CAJ85789)
DEFINITION Phospholipase A2, basic isoform precursor (Phosphatidylcholine)
SOURCE Deinagkistrodon acutus
COMMENT
[FUNCTION] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits ADP-induced platelet aggregation.
[CATALYTIC ACTIVITY] Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
[COFACTOR] Binds 1 calcium ion per subunit (By similarity).
[SUBUNIT] Homodimer (By similarity).
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Venom gland.
[SIMILARITY] Belongs to the phospholipase A2 family. Group II subfamily.
FEATURES EC_number="3.1.1.4"
ORIGIN
001 mrtlwivavl lvsveghllq fnkmikimtr knafpfytsy gcycgwggrg wpkdatdscc
061 fvhdccyqkl tgcspkwdiy pyswktgvii cgegtpceke icecdraaav clgenlrtyk
121 tkymfypdfl ckkpskqc
LENGTH 138 aa
MOLECULAR WEIGHT 15854 Da

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022 Phospholipase A2, acidic (Phosphatidylcholine 2-acylhydrolase) (PLA2)

No.022
LOCUS    Q7SID6(1IJLA)(1IJLB)
DEFINITION Phospholipase A2, acidic (Phosphatidylcholine 2-acylhydrolase) (PLA2).
SOURCE Deinagkistrodon acutus
COMMENT
[FUNCTION] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Inhibits ADP-induced platelet aggregation.
[CATALYTIC ACTIVITY] Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
[COFACTOR] Binds 1 calcium ion per subunit.
[SUBUNIT] Homodimer.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Venom gland.
[SIMILARITY] Belongs to the phospholipase A2 family. Group II subfamily.
FEATURES EC_number="3.1.1.4"
ORIGIN
001 sliqfetlim kvvkksgmfw ysaygcycgw gghgrpqdat drccfvhdcc ygkvtgcdpk
061 mdsytyseen gdivcggddp ckreicecdr vaavcfrdnl dtynsdtywr yptkncqeep
121 dpc
LENGTH 123 aa
MOLECULAR WEIGHT 14032 Da

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023 Acutolysin-A precursor (HI)

No.023
LOCUS    Q9PW35
DEFINITION Acutolysin-A precursor (HI).
SOURCE Deinagkistrodon acutus
COMMENT
[FUNCTION] This protein is a zinc metalloprotease from snake venom that possesses hemorrhagic activity.
[COFACTOR] Binds 1 calcium ion per subunit.
[COFACTOR] Binds 1 zinc ion per subunit.
[SUBUNIT] Monomer.
[SUBCELLULAR LOCATION] Secreted protein.
[TISSUE SPECIFICITY] Venom gland.
[SIMILARITY] Contains 1 peptidase M12B domain.
ORIGIN
001 miqvllvtic laafpyqgss iilesgnvnd yevvyprkvt alpkgavqqk yedamqyefk
061 vngepvvlhl eknkglfskd yseihyspdg rritthplve dhcyyrghir ndadstasis
121 acnglkghfk lqgemyliep mkmsyseaha vykygnveke deapkmcgvt qnwesyepik
181 kasqlivste fqrymeiviv vdhsmvkkyn gdsdkikawv yemintites ysylyidiil
241 sgleiwsekd linvetsaen tlksfgewra kdlihrishd naqlltatdf dgptiglayv
301 asmcdpkrsv gvvqdhssvn rlvaitlahe mahnlgvrhd egscscgsgy tcimspvins
361 evikyfsdcs yiqcreyisk enppcilnkp lrtdtvstpv sgnelleagk dyd
LENGTH 413 aa
MOLECULAR WEIGHT 46565 Da

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